Key result
Cardiac MRI and biopsy identify metastatic hepatocellular carcinoma initially misdiagnosed as hypertrophic cardiomyopathy.
Why the study?
Cardiac metastasis of hepatocellular carcinoma is rarely reported and can be misdiagnosed as hypertrophic cardiomyopathy, leading to diagnostic challenges.
Case Report (n=1)
Answers are grounded in this paper and cite their sources.
Cardiac metastasis may mimic hypertrophic cardiomyopathy; single-case evidence leaves open the diagnostic role of MRI and biopsy.
At present, cardiac metastasis of hepatocellular carcinoma is rarely mentioned in the literature. We report a hepatocellular carcinoma patient with cardiac metastasis misdiagnosed as hypertrophic cardiomyopathy in 2011. Two years later, on presentation of syncope, an abnormal ventricular septal size was recorded by ultrasound scan, and was subsequently shown by magnetic resonance imaging to be a tumour lesion. A myocardial biopsy confirmed infiltration of hepatocellular carcinoma. This observation underlines the risk of hepatocellular carcinoma cardiac metastasis, manifested in its infiltrative form as hypertrophic cardiomyopathy. In conclusion, we suggest that the ultrasound appearance of hypertrophic cardiomyopathy in hepatocellular carcinoma patients should be seen as a "red flag" and recommend the introduction of magnetic resonance imaging assessment of transplant candidates.
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Greco et al. (2017) conducted a case report in Hepatocellular carcinoma with cardiac metastasis (n=1). Cardiac metastasis of hepatocellular carcinoma was evaluated. A patient with hepatocellular carcinoma cardiac metastasis was initially misdiagnosed with hypertrophic cardiomyopathy until magnetic resonance imaging and biopsy confirmed the tumor lesion.
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