First-in-Man Simultaneous Aortic and Mitral Valve Transcatheter Implantation Using Patient-Customized Prostheses

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Severe mitral and aortic valve disease with porcelain aorta (n=1). Intervention: Simultaneous transcatheter aortic and mitral valve implantation (TAVR and TMVR). Primary outcome: Hemodynamic and clinical outcome.

Q: What does this research mean for the field?

Simultaneous transapical transcatheter mitral and aortic valve replacement is feasible and achieves excellent hemodynamics in high-risk patients with porcelain aorta, but carries a risk of severe apical bleeding. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Hendrik Ruge; Erion Xhepa; Michael Joner; Thomas Ried; Emin Imeri; Ulf Herold; Markus Krane; Ruediger S. Lange; Magdalena Erlebach

doi:10.1016/j.jaccas.2021.01.032

April 1, 2021JACC Case ReportsOpen Access

First-in-Man Simultaneous Aortic and Mitral Valve Transcatheter Implantation Using Patient-Customized Prostheses

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Why the study?

Valve disease in patients with porcelain aorta and severe peripheral artery disease presents a challenge for choosing appropriate therapy, especially in those at extremely high surgical risk.

Study Design

Type

Case Report (n=1)

Multicenter

No

PICO

P

Population

A 78-year-old man with severe mitral and aortic valve disease, porcelain aorta, and severe peripheral artery disease deemed at extremely high surgical risk.

I

Intervention / Comparator

Simultaneous transcatheter aortic and mitral valve implantation (TAVR and TMVR)

O

Primary Outcome

Hemodynamic and clinical outcome

Limitations

Severe apical bleeding caused by a ventricular tear required surgical treatment and blood transfusion.
Risk-benefit ratio needs critical assessment due to complications associated with transapical access and exchange of large-bore devices.
Single case report; larger studies are needed to better understand complication rates and outcomes.

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Abstract

Valve disease in the presence of porcelain aorta and severe peripheral artery disease challenge physicians in choosing the appropriate therapy. We used a total transcatheter approach, simultaneously implanting a dedicated mitral and aortic valve prosthesis treating a patient with mitral and aortic valve disease at an extremely high surgical risk. (Level of Difficulty: Advanced.)

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Cite This Study

Ruge et al. (2021) conducted a case report in Severe mitral and aortic valve disease with porcelain aorta (n=1). Simultaneous transcatheter aortic and mitral valve implantation (TAVR and TMVR) was evaluated on Hemodynamic and clinical outcome.

synapsesocial.com/papers/6acd9425571471ba9000c207 https://doi.org/10.1016/j.jaccas.2021.01.032

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First-in-Man Simultaneous Aortic and Mitral Valve Transcatheter Implantation Using Patient-Customized Prostheses

Study Design

PICO

Limitations

Ask about this paper

Abstract

Discussion

Cite This Study

First-in-Man Simultaneous Aortic and Mitral Valve Transcatheter Implantation Using Patient-Customized Prostheses

Study Design

PICO

Limitations

Ask about this paper

Abstract

Discussion

Cite This Study

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