Key result
Premature MI family history is linked to ~2.3-fold higher CRP levels in offspring.
Why the study?
It was unclear whether high CRP levels and increased carotid intima-media thickness coexist in adolescents and young adults with a family history of premature myocardial infarction.
Case-Control (n=100)
May signal early vascular risk in offspring of premature MI; hypothesis-generating and leaves open need for prospective validation before screening changes.
AIMS: To determine whether high C-reactive protein (CRP) levels and increased intima-media thickness of the common carotid arteries are coexistent in adolescents and young adults with a family history (FH) of premature myocardial infarction (MI). METHODS: 50 healthy young subjects whose parents had had premature MI and 50 control matched subjects were enrolled in the study. CRP levels and the intima-media thickness of the distal common carotid arteries were evaluated in all subjects. RESULTS: As compared with the control subjects, the offspring of patients with premature MI had a higher CRP concentration (mean +/- SD 8.8 +/- 2.6 versus 3.9 +/- 0.6 mg/l, p < 0.02) and greater intima-media thickness of the common carotid arteries (values for combined sides, mean +/- SD 0.48 +/- 0.02 versus 0.43 +/- 0.02 mm, p < 0.03). CONCLUSION: High serum levels of CRP and arterial structural changes are coexistent at an early age in subjects with an FH of premature MI.
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Magadle et al. (2003) conducted a case-control in Family history of premature myocardial infarction (n=100). Family history of premature myocardial infarction vs. Matched controls without a family history of premature myocardial infarction was evaluated on C-reactive protein (CRP) concentration (mg/l) (p=<0.02). Offspring of patients with premature myocardial infarction had significantly higher C-reactive protein concentrations (8.8 vs 3.9 mg/l) and greater carotid intima-media thickness (0.48 vs 0.43 mm) compared to controls.
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