Key result
Xanthelasma palpebrum is linked to higher risk of MI, severe atherosclerosis, and mortality independent of lipids.
Why the study?
Xanthelasma palpebrum is associated with increased risk of mortality, myocardial infarct, and severe atherosclerotic disease independently of lipid profile, but this risk is not widely recognized.
Is xanthelasma palpebrum associated with an increased risk of mortality and cardiovascular disease independently of lipid profile?
Is xanthelasma palpebrum associated with an increased risk of mortality and cardiovascular disease independently of lipid profile?
Xanthelasma palpebrum is an independent clinical marker for increased risk of mortality, myocardial infarction, and severe atherosclerosis regardless of lipid profile.
A 44-year old patient presents at the emergencies for a cut above his right eyebrow. Inspection reveals a bilateral bilateral xanthelasma palpebrum (XP). The blood analysis shows a normal cholesterol level: is this enough reassurance as to the patient's cardiovascular and mortality risk? This article reviews evidence showing that XP - a cholesterol papule on the eyelids - is associated with an increased risk for mortality, myocardial infarct and severe atherosclerotic disease, independently from the patient's lipid profile.
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Koshy et al. (2026) conducted a review in Xanthelasma palpebrum (n=1). Xanthelasma palpebrum was evaluated on Mortality, myocardial infarction, and severe atherosclerotic disease. Xanthelasma palpebrum is associated with an increased risk for mortality, myocardial infarction, and severe atherosclerotic disease, independently of the patient's lipid profile.
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