Key result
Transitioning to intravenous methamphetamine accelerates cardiomyopathy and triggers acute heart failure.
Why the study?
Intravenous methamphetamine use is associated with accelerated development of cardiomyopathy and severe cardiovascular complications compared to oral use.
Case Report (n=1)
Transitioning from oral to intravenous methamphetamine use can rapidly accelerate the development of severe cardiotoxicity, including acute heart failure and cardiomyopathy.
May hasten cardiomyopathy upon IV methamphetamine transition; hypothesis-generating case report requiring prospective validation.
Methamphetamine (MA) abuse is a significant public health issue in Malaysia, mainly due to its severe cardiovascular complications. Intravenous (IV) use is associated with heightened health risks, including accelerated development of cardiomyopathy and other cardiovascular diseases. We present a case of a 35-year-old man with a history of chronic MA abuse who experienced typical angina, heart failure, and aggressive behaviour. He had recently switched from an oral to a self-prepared intravenous MA route. He was diagnosed with methamphetamine-induced cardiomyopathy (MaCM). This case illustrates the escalation of CCF development and psychiatric consequences associated with the transition from oral to IV MA use. Early intervention and comprehensive, multidisciplinary management are crucial in addressing the increased risks posed by IV administration, particularly in preventing the rapid progression of severe cardiovascular complications.
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Jusoh et al. (2026) conducted a case report in Methamphetamine-associated cardiomyopathy (n=1). Intravenous methamphetamine use vs. Oral methamphetamine use was evaluated. Transitioning from oral to intravenous methamphetamine use accelerated cardiac damage, resulting in early-onset methamphetamine-associated cardiomyopathy and acute heart failure.
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