Key result
CRT and surgery are linked to lower 5-year mortality and progressive HF versus medical therapy.
Why the study?
Long-term results of medical and surgical treatment in patients with severe chronic heart failure were analyzed to assess comparative outcomes.
Cohort (n=90)
No
Answers are grounded in this paper and cite their sources.
May inform severe CHF management decisions; leaves open comparative long-term efficacy of MT, CRT, and surgery pending randomized data.
Objective: study was analysis of long-term results of medical and surgical treatment of patients with severe chronic heart failure (CHF).Materials and methods. We studied 90 patients with CHF III–IV functional class (FC) of NYHA, treated in A.N. Bakulev Scientific Center for Cardiovascular Surgery in 2007. All patients were divided into 3 groups: 30 patients who underwent conventional medical therapy (MT); 30 patients who underwent cardiac resynchronization therapy (CRT); 30 patients extremely severe category, which was performed orthotopic heart transplantation. Patients were followed up for 5 years to assess long-term results of treatment of CHF.Results. In patients with severe CHF, CRT (with respect to MT) significantly reduces the 5-year risk of total mortality, death from progressive heart failure, rehospitalization for heart failure, cardiac arrhythmias, need for heart transplantation, as well as helping to reduce FC of CHF, and an increase in ejection fraction the left ventricle.Conclusion. Surgical treatment of patients with severe CHF demonstrated a significant advantage over conventional MT in terms of improving the 5-year forecast.
No takes yet. Share an insight, caveat, or question.
Коцоева et al. (2016) conducted a cohort in Severe chronic heart failure (NYHA class III-IV) (n=90). Cardiac resynchronization therapy or orthotopic heart transplantation vs. Conventional medical therapy (MT) was evaluated on 5-year risk of total mortality, death from progressive heart failure, and rehospitalization. Cardiac resynchronization therapy and surgical treatment significantly reduced the 5-year risk of total mortality and progressive heart failure compared to conventional medical therapy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: