Magnetic Nanoparticles for Self-Regulating Temperature Magnetic Induction Hyperthermia: Current Challenges

This is the authors' abstract. We don't add key points for this paper.

Self-regulating magnetic induction hyperthermia (SMIH) represents a localized tumor therapeutic modality that utilizes the Curie temperature (Tc) of magnetic nanoparticles (MNPs) to realize the automatic control of the hyperthermia temperature, which has attracted extensive research attention. Although various low-Tc MNPs have been fabricated, three critical challenges hinder the clinical translation of SMIH. Regarding thermal performance parameters, the threshold values of Tc and heating efficiency for effective SMIH remain undetermined. In terms of intratumoral retention, rapid loss and redistribution of intratumoral MNPs severely weaken long-term thermal stability during repeated hyperthermia cycles. From the perspective of manufacturing, large-scale fabrication of well-dispersed low-Tc MNPs is still a technical challenge. This review systematically elaborates on the above three challenges and proposes future research directions to accelerate the clinical transformation of SMIH.