Key result
LVAD unloading fails to reduce cardiac fibrosis or improve capillary density in end-stage heart failure.
Why the study?
Limited data exist describing histologic and noncardiomyocyte function of human myocardium in end-stage heart failure and mechanisms impeding recovery after LVAD-induced remodeling.
Does LVAD-induced unloading improve capillary density and reduce cardiac fibrosis in patients with end-stage heart failure?
Observational (n=66)
Does LVAD-induced unloading improve capillary density and reduce cardiac fibrosis in patients with end-stage heart failure?
Absolute Event Rate: 25.7% vs 27.9%
p-value: p=0.50
Despite robust hemodynamic unloading with an LVAD, capillary density and fibrosis remain unchanged in end-stage heart failure, highlighting persistent maladaptive cellular processes.
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Farris et al. (2017) conducted an observational in End-stage heart failure (n=66). LVAD-induced unloading vs. Loaded hearts (prior to LVAD or no LVAD) was evaluated on Cardiac fibrosis area (p=0.50). In patients with end-stage heart failure, LVAD-induced unloading did not significantly reduce cardiac fibrosis (25.7% vs 27.9%; P=0.50) or capillary density compared with loaded hearts.
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