Antibiotic therapy affects functional behaviour in cystic fibrosis blood mononuclear cells

This is the authors' abstract. We don't add key points for this paper.

Cystic fibrosis (CF) is the most common life-shortening genetic disorder in the Caucasian population and is due to mutations at the CF transmembrane conductance regulator ( CFTR ) gene leading to dysfunction of the protein, which normally acts as a chloride channel. This basic defect is associated with a progressive and lethal lung disease [1]. Opportunistic respiratory infections are common in CF patients' lungs, making antibiotics an important part of the regular care. Antibiotic therapy indirectly restores adequate levels of functional F508delCFTR in CF lymphomonocytes