Key result
Gastric cancer-induced PTTM features severe pulmonary artery narrowing and 100% tissue factor expression.
Why the study?
Pulmonary tumor thrombotic microangiopathy is a rare and fatal malignancy-related pulmonary complication that is extremely difficult to diagnose ante mortem.
Observational (n=6)
No
Answers are grounded in this paper and cite their sources.
Supports tissue factor role in gastric cancer PTTM; leaves open targeted therapy trials.
Pulmonary tumor thrombotic microangiopathy (PTTM) is an uncommon and fatal malignancy-related pulmonary complication characterized by fibrocellular intimal proliferation of small pulmonary arteries and arterioles. It causes marked pulmonary hypertension, right-side heart failure, and sudden death. Diagnosis of PTTM is extremely difficult while the patient is alive. Here, we report a 44-year-old woman who presented with complaining of progressing dyspnea and pulmonary hypertension but with no history of cancer. She was diagnosed with PTTM caused by advanced gastric cancer ante mortem and was treated effectively with chemotherapy.
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Yoo et al. (2014) conducted an observational in Pulmonary tumor thrombotic microangiopathy (PTTM) induced by gastric carcinoma (n=6). Gastric carcinoma with metastasis to lungs was evaluated on Degree of luminal narrowing (stenosis rate) in pulmonary arteries and immunohistochemical reactivity for tissue factor, VEGF, and osteopontin.
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