Key result
Occult early gastric carcinoma can cause pulmonary tumor thrombotic microangiopathy presenting as acute progressive pulmonary hypertension, even without antemortem signs of primary malignancy.
Why the study?
Identification of primary cancer is valuable for diagnosing pulmonary tumor thrombotic microangiopathy, but primary malignancy can sometimes remain occult until autopsy.
Case Report (n=1)
Occult early gastric cancer can cause pulmonary tumor thrombotic microangiopathy presenting as acute progressive pulmonary hypertension, even without antemortem signs of primary malignancy.
Supports considering occult malignancy in unexplained acute PH; hypothesis-generating for PTTM, requiring prospective validation.
Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare and critical malignancy-related disease characterized by acute progressive pulmonary hypertension (PH). In most cases of PTTM, the cancer can be diagnosed in advance. Identification of the primary cancer is valuable for PTTM diagnosis. Here, we present the case of a patient with PTTM due to early gastric carcinoma in whom the diagnosis of malignant cancer was not revealed until macroscopic autopsy findings. This case highlights the importance of recognizing causative occult early gastric cancer leading to PTTM in cases of acute progressive PH.
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Noiri et al. (2024) conducted a case report in Pulmonary tumor thrombotic microangiopathy (PTTM) (n=1). Occult early gastric carcinoma was evaluated. Occult early gastric carcinoma can cause pulmonary tumor thrombotic microangiopathy presenting as acute progressive pulmonary hypertension, even without antemortem signs of primary malignancy.
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