The study demonstrates that mutated USP8 can directly cause systemic organ damage in Cushing's syndrome independent of pituitary hormone changes.
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Tamara González-Costa is first author on ‘ Systemic and cardiac pathology induced by a clinically relevant USP8 activating mutation’, published in DMM. Tamara is a postdoctoral researcher in the lab of José Luis de la Pompa at Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain, investigating the cellular and molecular mechanisms that drive cardiovascular development and disease.
No takes yet. Share an insight, caveat, or question.
A 2026 study conducted an editorial in Cushing's syndrome. Mutated USP8 (transgenic mouse model) was evaluated.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: