Oleanolic Acid Alleviates Diet-Induced Adiposity by Blocking Neovascularization and Macrophage Accumulation in C57BL/6 Mice

This is the authors' abstract. We don't add key points for this paper.

Objectives: Obesity is a major risk factor in the pathogenesis of cardiometabolic disorders. Most of obesity-related disorders are closely associated with vascular dysfunction. As fat mass increases in obesity, oxygen deficiency occurs, thus promoting adipose tissue vascularization. Additionally, local hypoxia induces adipokine expression and recruitment of pro-inflammatory macrophages. This study aimed to evaluate the effects of oleanolic acid on angiogenesis and inflammation in a diet-induced obese mice model.