Key result
Brassica oleracea extract lowers arterial blood pressure dose-dependently in rats via calcium channel-blocking activity.
Why the study?
Traditional claims of Brassica oleracea L. for hypertension lacked scientific authentication using in vivo and in vitro pharmacological techniques.
Does crude extract of Brassica oleracea lower blood pressure and induce vasorelaxation in a rat model?
Does crude extract of Brassica oleracea lower blood pressure and induce vasorelaxation in a rat model?
Brassica oleracea crude extract demonstrates hypotensive and vasorelaxant effects in preclinical rat models, likely mediated by calcium channel blockade, providing scientific basis for its traditional use in hypertension.
Hypotensive effects in normotensive rats remain hypothesis-generating; leaves open translation to human hypertension management.
BACKGROUND: Brassica oleracea L. (Brassicaceae), commonly known as cabbage, is usually used for dietary purposes and is also known for many medicinal uses, including blood pressure. OBJECTIVES: The current research study aimed to authenticate the traditional claims of B. oleracea L. for hypertension on a scientific basis using in vivo and in vitro pharmacological techniques. METHODS: Crude extract of B. oleracea L. was evaluated for its hypotensive and vasorelaxant effects in normotensive anesthetized wistar rats using an invasive blood pressure-measuring technique and isolated rat thoracic aorta, respectively. RESULTS: Normotensive anaesthetized rats used in experiments showed a gradual decrease in blood pressure parameters and heart rate when treated with Bo.Cr (0.1-100 mg/kg) comparable to verapamil (0.01-30 mg/kg). Whereas, in isolated aortic tissue, Bo.Cr (0.01-3 mg/ml) exhibited complete relaxation on high K+ [80 mM] and phenylephrine (1 µM)-mediated contractions. Crude extract at doses of 0.3 and 1 mg/ml also showed a reduction in response to Ca2+ concentration-response curves. CONCLUSION: Results indicate calcium channel-blocking activity, a possible cause of the blood pressure-lowering and vasodilator effects of B. oleracea.
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Mahwish Haroon (2026) studied Hypertension (Pre-clinical model) (n=42). Brassica oleracea crude extract (Bo.Cr) vs. Vehicle control and Verapamil was evaluated on Mean arterial pressure (MAP), systolic/diastolic blood pressure, and vasorelaxation (p=<0.01). Brassica oleracea crude extract produced a dose-dependent decrease in systolic, diastolic, and mean arterial blood pressure in normotensive rats, likely mediated by calcium channel-blocking activity.
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