Key result
Day-hospital IV iron safely enables diuretic adjustments in ~34% of older heart failure patients.
Why the study?
Despite clear ESC recommendations for intravenous iron supplementation in heart failure, real-world implementation remains inconsistent, especially among frail older adults with multimorbidity and limited ambulatory care access.
Does a dedicated Cardiogeriatric Iron Day Hospital (Iron-DH) program safely and effectively integrate intravenous iron therapy and therapeutic optimization for frail older adults with heart failure?
Observational (n=67)
Does a dedicated Cardiogeriatric Iron Day Hospital (Iron-DH) program safely and effectively integrate intravenous iron therapy and therapeutic optimization for frail older adults with heart failure?
A multidisciplinary day-hospital model for IV iron supplementation in frail older heart failure patients is feasible, safe, and allows for proactive therapeutic optimization.
May support integrated day-hospital models for IV iron in older HF patients; leaves open whether this improves outcomes versus standard care.
Background Iron deficiency (ID) is frequent in heart failure (HF) and is associated with poorer functional capacity, quality of life, and prognosis. Despite clear ESC recommendations for intravenous (IV) iron supplementation, real-world implementation remains inconsistent, particularly among frail older adults with multimorbidity and limited access to ambulatory care. Purpose To describe the design and early outcomes of a dedicated Cardiogeriatric Iron Day Hospital (Iron-DH) program— an organizational innovation integrating IV iron repletion within a multidisciplinary, telemonitored HF care pathway aimed at preventing avoidable readmissions. Methods Iron-DH delivers IV ferric carboxymaltose according to ESC guidelines, combined with comprehensive clinical, functional, and cognitive assessment. The program is embedded within a cardiogeriatric network linking day- hospital, telemonitoring, and community services. Beyond IV therapy, Iron-DH acts as a structured follow-up unit where patients are clinically reassessed, medication regimens reviewed, and early signs of congestion detected to avoid full rehospitalization. Functional capacity is evaluated using the six-minute walk test (6MWT) and Kansas City Cardiomyopathy Questionnaire (KCCQ); cognition by the Clock Drawing Test. Re-evaluation occurs 4–6 months later, either in day-hospital or through telemonitoring follow-up. Results Between January and June 2025, 421 HF patients were hospitalized; 224 (53.2 %) had ID and 67 (29.9 %) were managed in Iron-DH. All received IV iron safely. Diuretics were adjusted in 34.3 %, and 20.9 % were redirected to the Diuretic-DH. Mean 6MWT was 129 m and mean KCCQ 40.5. Iron-DH functioned as a post-discharge checkpoint, ensuring therapeutic optimization, early identification of relapse, and continuity between inpatient care, telemonitoring, and community management. Conclusion The Iron-DH model, integrated with telemonitoring and diuretic-day-hospital pathways, represents a reproducible, internationally transferable framework for proactive HF management. More than a site for IV supplementation, Iron-DH provides an opportunity to reassess clinical stability, adjust therapy, and intercept early decompensations. This multidisciplinary, patient-centered model exemplifies how organizational innovation can bridge evidence and practice, improving care quality and autonomy for frail older adults with HF .
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Esser et al. (2026) conducted an observational in Heart failure with iron deficiency (n=67). Cardiogeriatric Iron Day Hospital (Iron-DH) program was evaluated on Early clinical outcomes including safety, diuretic adjustments, and functional capacity. The Cardiogeriatric Iron Day Hospital safely administered IV iron to 67 older adults with heart failure, facilitating diuretic adjustments in 34.3% of patients.
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