Key result
Adding Yijinjing training improves post-PCI clinical response by ~30 percentage points over standard care.
Why the study?
The effects of Yijinjing training on cardiac rehabilitation in patients with Qi-deficiency and blood-stasis syndrome after PCI for AMI were not well established.
Does Yijinjing training improve myocardial microcirculation perfusion, cardiac function, and exercise capacity in patients with Qi-deficiency and blood-stasis syndrome following PCI for acute myocardial infarction?
RCT (n=70)
Single-blind (outcome assessor)
Random number table
No
Does Yijinjing training improve myocardial microcirculation perfusion, cardiac function, and exercise capacity in patients with Qi-deficiency and blood-stasis syndrome following PCI for acute myocardial infarction?
Absolute Event Rate: 90.91% vs 60.61%
p-value: p=<0.05
Yijinjing training added to standard secondary prevention safely improves myocardial microcirculation perfusion, left ventricular systolic function, and exercise endurance in post-PCI AMI patients.
Yijinjing may improve outcomes in select post-PCI patients; leaves open generalizability pending larger confirmatory trials.
ObjectiveTo investigate the effects of Yijinjing training on cardiac rehabilitation in patients with Qi-deficiency and blood-stasis syndrome following percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI).MethodsA total of 70 AMI patients with Qi-deficiency and blood-stasis syndrome who underwent PCI in the Department of Cardiology, Xiamen Hospital of Traditional Chinese Medicine from January to December 2024 were randomly assigned to a control group or an observation group, with 35 patients in each group. During this study, 2 patients in each group withdrew, were lost to follow-up, or had poor adherence, leaving 66 patients for final analysis. The control group received routine health education and standard secondary prevention medication for coronary heart disease, while the observation group additionally performed Yijinjing training for 12 weeks. Before and after treatment, cardiac magnetic resonance (CMR) was used to assess myocardial microcirculation parameters, including time to peak (tpeak), maximum upstroke slope (Slopemax), as well as left ventricular ejection fraction (LVEF). Serum nitric oxide (NO) was measured by enzyme-linked immunosorbent assay (ELISA). Cardiopulmonary exercise testing was performed using a symptom-limited incremental protocol on a cycle ergometer to determine maximal oxygen uptake (VO2max) and anaerobic threshold (AT). The Duke Activity Status Index (DASI) was used to assess daily physical activity capacity; the Short Form-36 (SF-36) was used to evaluate physical function, role physical, and vitality. The Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were used to assess psychological status. The traditional Chinese medicine (TCM) syndrome scores and clinical efficacy were evaluated, and adverse events were recorded throughout the treatment period.Results(1) Myocardial microcirculation parameters: compared with those before treatment, the tpeak decreased significantly in both groups after treatment (P0.05), while the Slopemax increased significantly (P0.05). Compared with the control group, the tpeak in the observation group was lower after treatment (P0.05), and the Slopemax was higher (P0.05). (2) LVEF and serum NO levels: compared with those before treatment, the LVEF and serum NO levels increased significantly in both groups after treatment (P0.05). Compared with the control group, the LVEF and serum NO levels in the observation group were higher after treatment (P0.05). (3) Cardiopulmonary function and exercise tolerance: compared with those before treatment, the VO2max, AT, and DASI scores increased significantly in the observation group after treatment (P0.05). Compared with the control group, the AT and DASI scores in the observation group were higher after treatment (P0.05). (4) Quality of life: compared with those before treatment, all dimensions of the SF-36 scores increased significantly in both groups after treatment (P0.05). Compared with the control group, the mental health scores in the observation group were higher after treatment (P0.05). (5) Psychological status: compared with those before treatment, the SAS and SDS scores decreased significantly in both groups after treatment (P0.05). Compared with the control group, the SAS and SDS scores in the observation group were lower after treatment (P0.05). (6) TCM syndrome scores and clinical efficacy: compared with those before treatment, the TCM syndrome scores decreased significantly in both groups after treatment (P0.05). Compared with the control group, the TCM syndrome scores in the observation group were lower after treatment (P0.05). The total effective rate of the observation group was 90.91%, higher than 60.61% of the control group (P0.05). No serious adverse events occurred in either group.ConclusionOn the basis of standardized Western medicine treatment, Yijinjing training can improve myocardial microcirculation perfusion, left ventricular systolic function, vascular endothelial function, exercise endurance, and mental state of patients with Qi-deficiency and blood-stasis syndrome after AMI-PCI, with favorable efficacy and safety.
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XU et al. (2026) conducted an RCT in Acute myocardial infarction with Qi-deficiency and blood-stasis syndrome post-PCI (n=70). Yijinjing training vs. Routine health education and standard secondary prevention medication was evaluated on Total clinical effective rate (based on TCM syndrome scores) (p=<0.05). Yijinjing training combined with standard care significantly increased the total clinical effective rate to 90.91% compared to 60.61% with standard care alone in patients with Qi-deficiency and blood-stasis syndrome after acute myocardial infarction percutaneous coronary intervention.
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