Key result
In patients with chronic kidney disease, heart failure with preserved ejection fraction was significantly more prevalent in terminal CKD stage 5 (72.0%) compared to stages 3-4 (47.3%).
Why the study?
The prevalence and clinico-demographic features of different CHF phenotypes in hospitalized patients with CKD were not well characterized.
Observational (n=396)
No
Absolute Event Rate: 72% vs 47.3%
p-value: p=<0.001
The study demonstrates that among patients with CKD and heart failure, HFpEF predominantly occurs in end-stage renal disease and is associated with cardiometabolic factors, whereas HFrEF is more prevalent in earlier CKD stages and is predominantly of ischemic origin.
Objective: To study the prevalence and clinico-demographic features of different phenotypes of chronic heart failure (CHF) in hospitalized patients with chronic kidney disease (CKD). Materials and Methods: A retrospective study included 396 patients with CHF and CKD, confirmed by reduced glomerular filtration rate (GFR less than 60 ml/min/1.73 m2). According to left ventricular ejection fraction (LVEF), patients were divided into three phenotypes: CHF with preserved LVEF (CHFpEF, >=50%), mid-range LVEF (CHFmrEF, 40-49%), and reduced LVEF (CHFrEF, less than 40%). Conclusion: Results show significant prevalence of CHF phenotypes in CKD patients with distinct clinico-demographic profiles across CKD stages.
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Rashidov et al. (2026) conducted an observational in Chronic heart failure and chronic kidney disease (n=396). Chronic kidney disease stage (Stage 5 vs Stages 3-4) vs. CKD Stages 3-4 was evaluated on Prevalence of heart failure with preserved ejection fraction (CHFpEF) (p=<0.001). In patients with chronic kidney disease, heart failure with preserved ejection fraction was significantly more prevalent in terminal CKD stage 5 (72.0%) compared to stages 3-4 (47.3%).
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