Why the study?
Independent factors influencing severe disease in elderly patients with community-acquired pneumonia complicated by heart failure were not well defined, and early identification tools were lacking.
Observational (n=140)
No
Effect estimate: AUC 0.891 (95% CI 0.818-0.963)
A novel nomogram combining procalcitonin, B-type natriuretic peptide, and impaired consciousness provides high predictive accuracy for identifying severe disease in elderly patients with concurrent community-acquired pneumonia and heart failure.
Supports nomogram for severe disease risk stratification in elderly CAP-HF; hypothesis-generating pending prospective validation.
Objective: To identify independent influencing factors of severe disease among old community-acquired pneumonia(CAP) patients complicated by heart failure(HF), and to establish the nomogram model for identifying severe illness early in clinical settings. Methodology: This was a retrospective study. Altogether 140 elderly patients with concurrent CAP and HF admitted into Baoding No.1 Central Hospital between January 2022 to November 2025. According to the CURB-65 (confusion, blood urea nitrogen, respiratory rate, systolic blood pressure, age ≥65 years) score, patients were classified as the non-high-risk(n =100) or high-risk(n =40) group. Later, demographic and baseline data, infection and inflammatory markers, cardiac and other organ function parameters, coagulation parameters, systemic parameters, and clinical manifestations were compared between these two groups. Results: After preliminary screening through univariate analysis, multivariate logistic regression identified procalcitonin(PCT), B-type natriuretic peptide(BNP), and impaired consciousness as independent predictors of severe disease(P< 0.05, respectively). These significant predictors were incorporated into a nomogram model to estimate individual risk. The ROC curve analysis showed that the combined model yielded an area under the curve of 0.891(95% confidence interval: 0.818–0.963). Moreover, our calibration curve closely aligned with the ideal curve, indicating that our predicted risk was highly consistent with the actual risk. As for clinical utility, the DCA revealed substantial net clinical benefits of our constructed model among a broad threshold probability spectrum(0.05–1.0). Conclusion: The nomogram model incorporating PCT, BNP, and impaired consciousness demonstrates greater predictive power than those using any single parameter alone. With good calibration and favorable clinical utility.
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Sun et al. (2026) conducted an observational in Community-acquired pneumonia complicated by heart failure (n=140). Combined nomogram model (procalcitonin, BNP, and impaired consciousness) vs. Single clinical parameters alone was evaluated on Prediction of severe disease (Area Under the Curve) (AUC 0.891, 95% CI 0.818-0.963).
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