Key result
SVC mass resection and reconstruction identifies a rare primary superior vena cava seminoma.
Case Report (n=1)
This case report highlights a rare incidence of a primary classic seminoma arising directly within the superior vena cava and causing superior vena cava syndrome.
Consider seminoma in atypical SVC mass differentials; extends the anatomic spectrum of extragonadal germ-cell tumors.
A 43-year-old man presented with a 1-month history of progressive facial and neck swelling without an identifiable trigger. He was diagnosed with superior vena cava syndrome (SVCS). A further chest CT showed an irregular low-density mass within the superior vena cava (SVC), and 18 F-FDG PET/CT showed significant tracer uptake. Malignancy was suspected. Among the tumor markers tested, only NSE was mildly elevated (33.4 ng/mL, normal range, <7 ng/mL). Subsequently, the patient underwent resection of the SVC mass combined with SVC replacement; the final pathologic diagnosis was classic seminoma.
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Jin et al. (2026) conducted a case report in Superior vena cava syndrome (SVCS) secondary to primary seminoma (n=1). Resection of the SVC mass combined with SVC replacement was evaluated on Pathologic diagnosis. Resection of an intravascular mass combined with superior vena cava replacement in a 43-year-old man revealed a rare case of primary classic seminoma arising in the superior vena cava.
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