Key result
Hybrid balloon occlusion of the LVAD outflow graft enables safe thrombus evacuation and successful SAVR.
Why the study?
Patients with durable left ventricular assist devices are at risk of developing significant aortic regurgitation and aortic thrombus, complicating management and limiting treatment options such as transcatheter aortic valve replacement.
Case Report (n=1)
In dLVAD patients with complicated aortic regurgitation and aortic thrombus, a hybrid surgical strategy utilizing interventional balloon occlusion of the outflow-graft and short circulatory arrest can facilitate safe thrombus removal and surgical aortic valve replacement.
Hybrid balloon-occlusion technique may enable safe AVR with thrombus evacuation in complex dLVAD cases; hypothesis-generating, requires prospective validation.
BACKGROUND: Patients with end-stage heart failure undergoing durable left ventricular assist device (dLVAD) implantation are at risk of developing de novo or progressive aortic regurgitation (AR) during long-term support. CASE SUMMARY: We report a dLVAD patient with significant AR, in whom transcatheter aortic valve replacement was unsuitable because of an enlarged aortic annulus and aortic thrombus. A complex hybrid approach included open thrombus removal from the ascending aorta under short circulatory arrest, temporary interventional occlusion of a not-accessible dLVAD outflow-graft, and surgical aortic valve replacement (SAVR). DISCUSSION: Aortic thrombus in dLVAD patients carries the risk of coronary, cerebral or peripheral embolism. In addition to this contraindication, SAVR was favored over transcatheter aortic valve replacement because of an aortic annulus diameter >28 mm, according to the institutional treatment algorithm. TAKE-HOME MESSAGE: In a dLVAD patient with AR and aortic thrombus, an individualized hybrid strategy enabled effective outflow-graft occlusion facilitating safe thrombus evacuation and SAVR.
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Stegmann et al. (2026) conducted a case report in Aortic regurgitation and dynamic aortic thrombus in a patient with left ventricular assist device (n=1). Hybrid surgical approach (interventional outflow-graft occlusion, circulatory arrest, thrombus removal, and SAVR) was evaluated on Procedural success and safe thrombus extraction without neurological complications. An individualized hybrid surgical strategy with temporary balloon occlusion of the outflow-graft enabled safe thrombus evacuation and successful surgical aortic valve replacement in a dLVAD patient.
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