Key result
Harmony transcatheter pulmonary valve implantation can cause left anterior descending coronary artery compression.
Why the study?
Patients with tetralogy of Fallot often develop pulmonary regurgitation after transannular patch repair, and the risk of coronary compression with the Harmony transcatheter pulmonary valve requires evaluation.
Does Harmony transcatheter pulmonary valve implantation result in left anterior descending coronary artery compression in patients with tetralogy of Fallot?
Case Report
Does Harmony transcatheter pulmonary valve implantation result in left anterior descending coronary artery compression in patients with tetralogy of Fallot?
This report highlights a critical complication of left anterior descending coronary artery compression following Harmony transcatheter pulmonary valve implantation, despite its design intended to minimize this risk.
Harmony TPV may reduce coronary compression risk after TOF repair; leaves open durability and safety in larger prospective cohorts.
Patients with tetralogy of Fallot frequently develop pulmonary regurgitation following transannular patch repair. Percutaneous pulmonary valve implantation has been increasingly adopted for these patients.1 The Harmony transcatheter pulmonary valve (Medtronic) is a porcine pericardial valve mounted on a self-expanding nitinol frame covered with polyester fabric. Its asymmetric hourglass design, characterized by a narrow central waist, has been reported to confer a low risk of coronary compression.
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Un et al. (2026) conducted a case report in Tetralogy of Fallot with pulmonary regurgitation. Harmony transcatheter pulmonary valve implantation was evaluated. Harmony transcatheter pulmonary valve implantation can be associated with left anterior descending coronary artery compression.
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