Key result
Living over 30 km from the hospital is linked to ~9.6-fold higher odds of delayed stroke presentation.
Why the study?
Timely presentation after ischemic stroke is critical for optimal management and improved outcomes, but delays and their predictors are not well characterized in Northern Ethiopia.
Cross-Sectional (n=200)
No
Odds Ratio: 9.569 (95% CI 3.119–29.361)
p-value: p=0.001
A large majority of patients with ischemic stroke in Northern Ethiopia present well beyond the window for thrombolysis, driven by long distances, lack of vehicle transport, and poor symptom awareness.
May inform targeted prehospital interventions in similar settings; hypothesis-generating for generalizability beyond Northern Ethiopia.
Stroke is a leading cause of morbidity and mortality worldwide, with ischemic stroke being the most common subtype. Timely presentation is critical for optimal management and improved outcomes. A prospective observational study was conducted at the University of Gondar Comprehensive Specialized Hospital from July to September 2022. Time from symptom onset to hospital arrival and factors associated with delayed presentation were assessed. Data were collected using a structured questionnaire, entered into EpiData version 4.6, and analyzed using SPSS version 23. A total of 200 ischemic stroke patients were included, with a median age of 65 years (IQR: 20 years), and 57.5% were female. Most patients (71.0%, n = 142) presented after the 4.5-hour therapeutic window. The median time to presentation was 12 h (IQR: 4 h). Factors associated with delayed presentation included distance greater than 30 km from the hospital, non-vehicle transportation, absence of a caretaker or bystander, absence of altered mentation as an initial symptom, and lack of prior stroke awareness. A high proportion of patients presented late, limiting eligibility for reperfusion therapy. Interventions to improve stroke awareness, transportation systems, and early symptom recognition are essential.
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Adgah et al. (2026) conducted a cross-sectional in Acute ischemic stroke (n=200). Distance > 30 km from hospital vs. Distance < 5 km from hospital was evaluated on Delayed hospital presentation (>4.5 hours after symptom onset) (AOR 9.569, 95% CI 3.119-29.361, p=0.001). Among patients with acute ischemic stroke, 71.0% presented beyond the 4.5-hour therapeutic window, with distance greater than 30 km from the hospital significantly increasing the odds of delayed presentation (AOR 9.569).
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