Key result
Conservative management stabilizes high-risk saddle PE in pregnancy, safely avoiding thrombolysis.
Why the study?
Pulmonary embolism in late pregnancy presents diagnostic and management challenges, especially in severe cases without hemodynamic instability and with fetal compromise.
Does conservative management with therapeutic anticoagulation and high-flow oxygen improve maternal and fetal outcomes in a hemodynamically stable pregnant patient with high-risk (sub-massive) pulmonary embolism and right ventricular strain?
Case Report (n=1)
Does conservative management with therapeutic anticoagulation and high-flow oxygen improve maternal and fetal outcomes in a hemodynamically stable pregnant patient with high-risk (sub-massive) pulmonary embolism and right ventricular strain?
Even extensive saddle pulmonary embolism in pregnancy can be successfully managed without thrombolysis using therapeutic anticoagulation and high-flow oxygen when the mother remains hemodynamically stable.
Supports considering conservative management in stable pregnant submassive PE; hypothesis-generating pending prospective studies.
Pregnancy increases the risk of venous thromboembolism, and pulmonary embolism (PE) remains a leading cause of maternal morbidity and mortality. Diagnosis is challenging due to symptom overlap with normal pregnancy, and management is complex in severe cases without hemodynamic instability. A 32-year-old woman at 32 weeks' gestation presented with dyspnea, chest pain, and hypoxemia. CT pulmonary angiography confirmed a saddle PE with right ventricular strain. Despite high oxygen requirements, she remained hemodynamically stable. She was managed in the intensive care unit with therapeutic anticoagulation and high-flow oxygen, while thrombolysis was deferred due to bleeding risk. Fetal monitoring showed intermittent nonreassuring findings likely related to maternal hypoxia. Following multidisciplinary discussion, conservative management was continued. The patient improved clinically, was discharged on low-molecular-weight heparin, and later delivered at 39 weeks with good maternal and neonatal outcomes.
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Abushamma et al. (2026) conducted a case report in Pulmonary embolism during pregnancy (n=1). Conservative management (therapeutic anticoagulation and high-flow oxygen) was evaluated on Maternal and fetal clinical outcomes. Conservative management with therapeutic anticoagulation and high-flow oxygen successfully stabilized a pregnant patient with a high-risk saddle pulmonary embolism and fetal compromise, avoiding thrombolysis.
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