Key result
Periodontitis is linked to a worse vascular risk phenotype in adolescents.
Why the study?
Periodontal tissue disruption and vascular dysfunction may coexist in adolescence, indicating early manifestations of vascular risk may be detectable at this stage.
Is periodontitis associated with an increased vascular risk phenotype in late adolescence?
Cross-Sectional (n=2,515)
Is periodontitis associated with an increased vascular risk phenotype in late adolescence?
Effect estimate: Standardized Coefficient 0.100
p-value: p=0.004
Periodontal tissue disruption and vascular dysfunction co-occur in late adolescence, indicating that early manifestations of cardiovascular risk are already detectable and influenced by shared metabolic determinants.
No practice change indicated by observational link; leaves open causal role of periodontitis in vascular risk.
OBJECTIVE: We hypothesized that periodontal tissue disruption and vascular dysfunction may coexist in adolescence, indicating that early manifestations of vascular risk may already be detectable at this stage of the life course. METHODS: A population-based sample of 2515 adolescents aged 18-19 years was obtained from the RPS Cohort and additional sources. We examined the relationships between Periodontitis (a latent variable representing the shared variance of bleeding on probing, probing depth ≥ 4 mm, and clinical attachment loss ≥ 3 mm) and the Vascular Risk Phenotype (a latent variable formed by carotid-femoral pulse wave velocity, systolic and diastolic blood pressure). Socioeconomic status, smoking, alcohol, and obesity were adjusted in structural equation models. RESULTS: Periodontitis and Vascular Risk Phenotype were correlated [Standardized Coefficient (SC): 0.100; p = 0.004]. A higher socioeconomic status was negatively associated with both Periodontitis (SC: -0.112; p < 0.001) and Vascular Risk Phenotype (SC: -0.061; p = 0.04). The strongest association was observed between obesity and the Vascular Risk Phenotype (SC: 0.393; p < 0.001), followed by its association with Periodontitis (SC: 0.114; p < 0.001). CONCLUSION: Periodontal and vascular alterations appear to co-occur and may represent early manifestations of cardiovascular risk influenced by shared socioeconomic and metabolic determinants.
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Costa et al. (2026) conducted a cross-sectional in Periodontitis and Vascular Risk (n=2,515). Periodontitis was evaluated on Correlation between Periodontitis and Vascular Risk Phenotype (Standardized Coefficient 0.100, p=0.004). Periodontitis was significantly correlated with a higher vascular risk phenotype, including blood pressure and pulse wave velocity, in adolescents (Standardized Coefficient 0.100; p=0.004).
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