Key result
Age over 65 linked to ~5 percentage points lower CTO-PCI procedural success.
Why the study?
The influence of age on procedural success and clinical outcomes in PCI for coronary chronic total occlusion is controversial.
Does older age impact the procedural success and clinical outcomes of patients undergoing percutaneous coronary intervention for coronary chronic total occlusion?
Cohort (n=1,283)
No
Does older age impact the procedural success and clinical outcomes of patients undergoing percutaneous coronary intervention for coronary chronic total occlusion?
Absolute Event Rate: 77.7% vs 82.7%
p-value: p=0.023
Older age (>65 years) does not impact the technical success of CTO-PCI but is associated with lower procedural success due to an increased risk of in-hospital adverse events.
Background and purpose: The influence of age on procedural success and clinical outcomes in percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) is controversial. This study aimed to evaluate the impact of age on procedural success and clinical outcomes in patients undergoing CTO-PCI. Methods: A total of 1,348 CTO-PCIs performed in 1,283 patients between 2019 and 2021 were retrospectively analyzed. Patients were stratified by age. Outcomes included technical success, procedural success, procedural complications, and in-hospital clinical events. Results: Among the 1,283 patients, the mean age was 60.5 ± 11.5 years, and 1,113 (86.7%) were men. Overall technical and procedural success rates were 81.8% and 80.9%, respectively. Age >65 years was associated with a lower procedural success rate (82.7% vs. 77.7%, P = 0.023) and a higher rate of in-hospital adverse events (0.8% vs. 1.4%, P = 0.036). However, the technical success rate and procedural complications were comparable. Conclusions: Age was not associated with technical success in CTO-PCI. However, older age was associated with lower procedural success, potentially because of the higher in-hospital adverse event rates following the procedure.
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Deng et al. (2026) conducted a cohort in coronary chronic total occlusion (n=1,283). Age >65 years vs. Age ≤65 years was evaluated on Procedural success (p=0.023). Older age (>65 years) in patients undergoing PCI for chronic total occlusion was associated with lower procedural success (77.7% vs 82.7%, P=0.023) compared to younger patients.
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