Key result
Immunosuppression plus anticoagulation completely resolves a giant right atrial thrombus at 3 months.
Why the study?
Intracardiac thrombus formation is a rare but potentially life-threatening cardiovascular manifestation of Behçet's disease, predominantly involving the right heart.
Case Report (n=1)
Intracardiac thrombus is a rare but severe manifestation of Behçet's disease that can present with extensive venous thrombosis, and it can be successfully treated with combined immunosuppressive therapy and anticoagulation when pulmonary artery aneurysms are absent.
Supports medical management of Behçet's-related right atrial thrombus; hypothesis-generating pending prospective validation.
Behçet's disease is a systemic vasculitis in which intracardiac thrombus formation is a rare but potentially life-threatening manifestation, predominantly involving the right heart. We report the case of a 37-year-old male presenting with pulmonary embolism associated with extensive central venous thrombosis and a giant right atrial thrombus, leading to the diagnosis of Behçet's disease based on the 2014 International Criteria. Multimodality imaging using transthoracic echocardiography and contrast-enhanced computed tomography revealed a large heterogeneous right atrial thrombus and superior vena cava thrombosis. The patient was managed medically with a favorable evolution. Intracardiac thrombus should raise suspicion for Behçet's disease in young patients with atypical venous thrombosis, as early diagnosis and immunosuppressive therapy are crucial for favorable outcomes.
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Boutargante et al. (2026) conducted a case report in Behçet's disease with right atrial thrombus and central venous thrombosis (n=1). Systemic corticosteroids, intravenous cyclophosphamide, and anticoagulation was evaluated on Resolution of intracardiac thrombus. Treatment with systemic corticosteroids, intravenous cyclophosphamide, and anticoagulation led to complete resolution of a giant right atrial thrombus and clinical improvement at 3-month follow-up.
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