Key result
Elevated serum uric acid is linked to subclinical atherosclerosis and increased CIMT in young hemodialysis patients.
Why the study?
Hyperuricemia contributes to chronic kidney disease progression and cardiovascular risk, but its association with subclinical atherosclerosis in hemodialysis patients requires assessment.
Does serum uric acid concentration correlate with carotid intima-media thickness and subclinical atherosclerosis in young adult hemodialysis patients?
Cross-Sectional (n=90)
Yes
Does serum uric acid concentration correlate with carotid intima-media thickness and subclinical atherosclerosis in young adult hemodialysis patients?
In young adult hemodialysis patients, hyperuricemia is significantly associated with subclinical atherosclerosis and increased carotid intima-media thickness, suggesting its potential as an early cardiovascular risk marker.
Hyperuricemia may mark higher cardiovascular risk in young hemodialysis patients; hypothesis-generating and should not yet change practice.
Background: Hyperuricemia accelerates chronic kidney disease progression and raises cardiovascular risk via endothelial dysfunction and inflammation, with carotid intima-media thickness (CIMT) acting as a noninvasive marker for subclinical atherosclerosis and cardiovascular events. Aim: To assess the association between CIMT and serum uric acid concentration in hemodialysis patients. Subjects and methods: This research was a cross-sectional study performed over one year at the nephrology unit of Al-Azhar University Hospitals and Ahmed Maher Teaching Hospital in Egypt, involving 90 hemodialysis patients. Written informed consent was obtained from all participants, outlining the study's value and the procedures conducted. Results: In young adult hemodialysis patients, elevated serum uric acid concentration correlates significantly with elevated rates of hypertension, dyslipidaemia, adverse lipid profiles, elevated CIMT, and subclinical atherosclerosis. However, demographic factors, diabetes, smoking, coronary artery disease, dialysis duration, and vital signs showed no significant variances. Conclusion: Hyperuricemia is prevalent among cases with end-stage renal disease (ESRD) having hemodialysis, and it is associated with cardiovascular issues, indicated by higher rates of subclinical atherosclerosis and related complications. Uric acid levels may serve as an early marker for vascular involvement in these patients.
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Hassan et al. (2026) conducted a cross-sectional in End-stage renal disease on hemodialysis (n=90). Elevated serum uric acid concentration (Hyperuricemia) was evaluated on Association between carotid intima-media thickness (CIMT) and serum uric acid concentration. Elevated serum uric acid concentration significantly correlated with higher rates of hypertension, dyslipidaemia, elevated CIMT, and subclinical atherosclerosis in young adult hemodialysis patients.
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