Key result
Lower serum magnesium is linked to more severe hypertension and poorer blood pressure control.
Why the study?
Variations in risk factors such as serum magnesium level may contribute to the severity of hypertension, but their relationship is not well defined.
Cross-Sectional (n=150)
No
p-value: p=<0.05
Lower serum magnesium levels are significantly associated with more severe hypertension (requiring multiple medications), uncontrolled blood pressure, and obesity in hypertensive patients.
Does not support magnesium supplementation yet; leaves open causal effects for prospective trials.
Background: Hypertension is a significant global health problem that is mainly related to cardiovascular diseases and cerebrovascular complications. Variations in the levels of risk factors for this condition, such as a diet high in salt and low in potassium, obesity, consumption of alcohol, lack of activity, and poor lifestyle habits, might be responsible fora portion of the regional heterogeneity in the prevalence of hypertension. This study assessed the relation between serum magnesium level and the severity of hypertension.Methods: In a cross sectional study from 2nd October 2024 to the end of December 2024, 150 patients with hypertension from Al-Hakim General Hospital were enrolled. The number of antihypertensive drugs used for the treatment was considered as a marker for severity of hypertension. All participants underwent evaluation for coronary artery disease and stroke. The xylidyl blue method (magnesium liquicolor-human kit) was used to assess the level of serum magnesium in sera of the patients.Results: Patients who needed a multiple antihypertensive medication had lower serum magnesium level and demonstrated a significant inverse relationship between serum magnesium level and the number of antihypertensive medications taken. Patients with managed and uncontrolled hypertension exhibited a significant difference in serummagnesium concentration, with those with uncontrolled blood pressure having a lower magnesium level. Serum magnesium level was significantly lower in obese patients than in normal-weight and overweight persons.Conclusion: Hypertensive patients who needed multiple antihypertensive drugs showed a significantly lower serum magnesium level.
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M.Baqer et al. (2026) conducted a cross-sectional in Hypertension (n=150). Lower serum magnesium levels vs. Normal or higher serum magnesium levels was evaluated on Severity of hypertension (indicated by the number of antihypertensive medications and blood pressure control status) (p=<0.05). Lower serum magnesium levels were significantly associated with more severe hypertension, characterized by the need for multiple antihypertensive medications and uncontrolled blood pressure.
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