The effect of antihypertensive drugs on serum magnesium level

Abstract hypertension is a complicated condition in which many mechanisms collaborate, causing cardiovascular and cerebrovascular implications that are now among the most common causes of death, illness, and medical expenses globally. Currently, 1.13 billion individuals are suffering from hypertension, as reported by the World Health Association. The level of incidence of hypertension rises substantially with age, and due to the continuing aging of the population around the world, both the overall incidence of hypertension and the adverse outcomes continue to keep growing. Some clinical trials and reports suggest that hypertensive individuals possess a deficient serum magnesium level, with reduced levels of magnesium connected to adverse consequences on blood pressure levels. The aim of the study was to evaluate the effect of antihypertensive drugs on serum magnesium levels. The materials and methods of this study include 150 individuals with hypertension who have been recruited in this research from Al-Hakim General Hospital between October 2, 2024, and December 31, 2024. The concentration of magnesium in the patients' serum was determined by the xylidyl blue technique (magnesium liquicolor-human reagent). The results illustrate that patients with hypertension using beta-blocker drugs had significantly low serum magnesium levels. Conclusion: Hypertensive patients taking antihypertensive drugs, particularly beta blockers, had a reduced mean serum magnesium level.