Key result
Premature birth linked to cardiomyocyte contractile disruption with myofibril lysis and mitochondrial damage in rats.
Why the study?
Structural and functional disturbances of the cardiomyocyte contractile apparatus in premature rats were not fully characterized.
Answers are grounded in this paper and cite their sources.
The contractile apparatus of left-ventricular cardiomyocytes from from 180-day-old rats that had been born one day preterm was studied using polarization microscopy and transmission electron microscopy. In cardiomyocytes from preterm rats, the myofibrils had non-uniform thickness: along with thinned and disintegrated areas of myofibrils, thickened myofibrils were detected. Myofibril lysis was predominantly focal and less frequently diffuse. Cardiomyocytes with subsegmental contractures were observed. Mitochondria with signs of destruction were detected in cardiomyocytes from premature rats, while numerous small mitochondria that did not form intermitochondrial junctions were found in the dilated intermyofibrillar spaces. Mitochondrial damage leads to structural and functional disturbances of the cardiomyocyte contractile apparatus.
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Иванова et al. (2026) studied Prematurity. Premature birth was evaluated on Cardiomyocyte structural changes. Premature birth in rats was associated with structural disturbances of the cardiomyocyte contractile apparatus, including myofibril lysis and mitochondrial damage.
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