Key result
Harmonic bioimpedance analysis non-invasively detects autonomic nervous system activity in hypertension.
Why the study?
Non-invasive methods to assess autonomic nervous system activity and arterial pulsatile activity in perirenal dorsal lumbar regions in healthy and hypertensive patients are needed to evaluate autonomic function and guide therapy.
Does harmonic analysis of electrical bioimpedance and biopotentials non-invasively assess autonomic nervous system activity in healthy volunteers and patients with arterial hypertension?
Observational
Does harmonic analysis of electrical bioimpedance and biopotentials non-invasively assess autonomic nervous system activity in healthy volunteers and patients with arterial hypertension?
Harmonic analysis of electrical signals in perirenal regions provides a novel non-invasive tool to evaluate local autonomic nervous system activity, which may help guide pharmacotherapy or identify candidates for renal denervation in hypertension.
To non-invasively assess the activity of the autonomic nervous system (ANS) and the pulsatile activity of arteries in the perirenal dorsal lumbar regions, electrical bioimpedance (BI) and biopotentials (BP) were recorded in healthy volunteers and patients with arterial hypertension (AH). Signals were processed using harmonic (Fourier) analysis to determine the effective values (rms) of spectral peaks for BI (MR, THR) and BP (MV, THV) in the Mayer (M) frequency range (0.03-0.2 Hz) and the Traube–Hering (TH) frequency band of a controlled respiration rate (0.3-0.4 Hz), which presumably reflect sympathetic and parasympathetic activity, respectively. The pulsatile activity of arteries was determined by the total effective value (TPrms) of four pulsatile harmonics. The indices of the sympathetic–parasympathetic balance were calculated as the ratios of MR/THR (for BI) and MV/THV (for BP). In healthy participants, the active orthostatic test significantly increased THR, MR, TPrms -1 , and MV, which reflected increased activity of sympathetic (MR, TPrms -1 , MV) and parasympathetic (THR) systems while maintaining overall autonomic balance. The spectral parameters of BI and BP were presented with normalized radar charts (RC). In patients with controlled AH, the median RCs were located within the interquartile range of RC of the healthy group indicating adequate drug therapy. In contrast, individual RCs of some patients with uncontrolled or refractory AH were outside this range, indicating the need to correct drug therapy or feasibility of renal denervation if pharmacotherapy fails. The advanced method enables the assessment of ANS activity in patients with AH of varying severity. It is concluded that harmonic analysis of electrical signals in human perirenal regions is a valuable non-invasive tool for evaluating local activity of ANS under physiological conditions and in AH patients.
No takes yet. Share an insight, caveat, or question.
Makarov et al. (2026) conducted an observational in Arterial hypertension. Arterial hypertension vs. Healthy volunteers was evaluated on Spectral peaks for electrical bioimpedance and biopotentials reflecting autonomic nervous system activity. Harmonic analysis of electrical bioimpedance and biopotentials enabled non-invasive assessment of autonomic nervous system activity in healthy volunteers and patients with arterial hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: