Key result
Hypoxemia affects ~two-thirds of ED acute heart failure patients and tracks with worse prognosis.
Why the study?
The incidence of hypoxemia and the indications for oxygen therapy in patients with acute heart failure are not well known.
Observational (n=18,904)
Yes
Impaired oxygenation affects nearly two-thirds of emergency department patients with acute heart failure and is associated with increased severity and worse prognosis.
May inform initial risk assessment in ED acute HF; extends observational data but leaves optimal targets for trials.
INTRODUCTION: The incidence of hypoxemia and the indications for oxygen therapy in patients with acute heart failure (AHF) are not well known. METHODS: A large nationwide registry of unselected AHF patients attended in the emergency department (ED) was analysed. Oxygen saturation by pulse-oximetry (SpO RESULTS AND DISCUSSION: Of 18,904 AHF patients, 6949 (36.7%) had normal SpO CONCLUSIONS: Impaired oxygenation was observed in nearly two thirds of patients with AHF attended in ED. Hypoxemia occurred in 40% of those hospitalized, affecting all phenotypes and was associated with more severity and worse prognosis. This should be considered when addressing treatment recommendations for these patients.
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Masip et al. (2026) conducted an observational in Acute heart failure (AHF) (n=18,904). Hypoxemia vs. Normal oxygen saturation was evaluated on Severity and prognosis. Hypoxemia was present in nearly two-thirds of acute heart failure patients in the emergency department and was associated with greater disease severity and worse prognosis.
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