The Relationship of Renalase with Diurnal Blood Pressure Rhythm, Left Ventricular Mass Index and Carotid Intima–media Thickness in Autosomal Dominant Polycystic Kidney Disease

This study investigated the relationship between renalase and diurnal blood pressure (BP) rhythm, left ventricular mass index (LVMI) and carotid intima-media thickness (IMT) in autosomal dominant polycstic kidney disease (ADPKD) patients. The study included 59 ADPKD patients and 36 healthy volunteers. Renalase, noradrenalin, adrenaline, creatinine (Cr) and spot urine microalbumin-Cr ratio were studied; 24-h ambulatory BP and carotid IMT were measured, and LVMI was calculated. The ADPKD group comprised 21 hypertensive and 38 normotensive patients, and the control group comprised 36 healthy participants. Renalase levels were significantly higher in hypertensive and normotensive ADPKD patients than in the control group (69.7 ± 90.02 ng/mL and 91.93 ± 106.55 ng/mL vs. 16.9 ± 51.4 ng/mL; P = 0.042 and P = 0.001, respectively). The renalase levels were higher in the hypertensive ADPKD group than in the normotensive ADPKD group but they were not statistically significant (91.93 ± 106.55 ng/mL vs. 69.7 ± 90.02 ng/mL; P = 0.486). LVMI was significantly higher in the hypertensive ADPKD group compared with the normotensive ADPKD and control groups (92.2 ± 20.9 vs. 76.2 ± 16.89 and 68.6 ± 12.75; P = 0.02 and P = 0.001, respectively). There was no statistically significant difference in carotid IMT between the groups (0.59 ± 0.16, 0.65 ± 0.17 and 0.58±0.1; P = 0.442, respectively). Renalase levels were significantly higher in the normotensive ADPKD and hypertensive ADPKD groups compared with the control group, but its relationship with circadian BP rhythm, LVMI and carotid IMT was not demonstrated.