Why the study?
Do sodium reduction and enalapril administration affect blood pressure and RAS hormonal responses differently in hypertensive ADPKD patients compared to essential hypertension controls?
Population
11 hypertensive autosomal-dominant polycystic kidney disease patients and 8 matched control subjects with…
Comparison
Two different sodium intakes and the… vs Placebo and matched control subjects with…
Design
RCT, double-blind
Follow-up
5 days for sodium intake, 3 days for enalapril
Authors
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Supports equivalent sodium restriction and enalapril use in hypertensive ADPKD; confirms no greater circulating RAS activation than in essential hypertension.
Do sodium reduction and enalapril administration affect blood pressure and RAS hormonal responses differently in hypertensive ADPKD patients compared to essential hypertension controls?
Activation of the classic circulating renin-angiotensin system is no greater in hypertensive ADPKD patients than in individuals with essential hypertension.
Doulton et al. (2006) studied this question.
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