Key result
Beetroot juice is evaluated for blood pressure reduction in hypertensive ADPKD.
Why the study?
Impaired nitric oxide synthesis contributes to early-onset hypertension in ADPKD, and the effect of beetroot juice on blood pressure in this population has not been tested.
RCT (n=60)
Double-blind
1:1 simple randomisation
No
Answers are grounded in this paper and cite their sources.
Tests nitrate-rich beetroot juice for BP reduction in ADPKD hypertension; first RCT to evaluate this in treated patients.
BACKGROUND: In autosomal dominant polycystic kidney disease (ADPKD) impaired nitric oxide (NO) synthesis, in part, contributes to early-onset hypertension. Beetroot juice (BRJ) reduces blood pressure (BP) by increasing NO-mediated vasodilation. The aim of this double-blind, randomised, placebo-controlled study is to test the hypothesis that BRJ reduces systolic and diastolic clinic BP in hypertensive adults with ADPKD. METHODS: Participants with ADPKD and treated hypertension (n = 60) will be randomly allocated (1:1) to receive a daily dose of either nitrate-replete (400 mg nitrate/day) or nitrate-deplete BRJ for 4 weeks. The co-primary outcomes are change in mean systolic and diastolic clinic BP before and after 4 weeks of treatment with daily BRJ. Secondary outcomes are changes in daily home BP, urinary albumin to creatinine ratio, serum and salivary nitrate/nitrite levels and serum asymmetric dimethylarginine levels before and after 4 weeks of BRJ. DISCUSSION: The effect of BRJ in ADPKD has not been previously tested. BRJ is an accessible, natural dietary supplement that, if effective, will provide a novel adjunctive approach for treating hypertension in ADPKD. TRIAL REGISTRATION: ClinicalTrials.gov NCT05401409. Retrospectively registered on 27th May 2022.
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Sagar et al. (2023) conducted an RCT in Autosomal Dominant Polycystic Kidney Disease and Hypertension (n=60). Beetroot juice vs. Nitrate-deplete beetroot juice placebo was evaluated on Change in mean systolic and diastolic clinic blood pressure from baseline to after 4 weeks of treatment. Daily beetroot juice supplementation containing of nitrate will be evaluated for its efficacy in reducing clinic blood pressure in a randomized, double-blind trial of 60 hypertensive adults with autosomal dominant polycystic kidney disease.
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