Key result
TAVR complications remain multifactorial and evolve with advancing device design and procedural technique.
Why the study?
Procedure-related complications following transcatheter aortic valve replacement remain clinically important, with evolving incidence and management due to newer devices and techniques.
What are the incidence, risk factors, and management of major complications following transcatheter aortic valve replacement in patients with severe aortic stenosis?
What are the incidence, risk factors, and management of major complications following transcatheter aortic valve replacement in patients with severe aortic stenosis?
TAVR complications are multifactorial and their management continues to evolve, highlighting the ongoing need for optimized patient selection, procedural refinement, and individualized antithrombotic strategies.
Shifting TAVR complications may warrant refined selection and antithrombotic strategies; leaves open optimal regimens pending prospective data.
Background Severe aortic stenosis (As) is the most common valvular heart disease in developed countries, and transcatheter aortic valve replacement (TAVR) has expanded across surgical risk groups. However, procedure-related complications remain clinically important, and their reported incidence and management have evolved with newer-generation devices and techniques. This review summarizes major TAVR complications, including their incidence and pathophysiology, risk factors, clinical impact, prevention and management, and outlines remaining knowledge gaps. Materials and methods A structured narrative review of PubMed/MEDLINE, Scopus, and Web of Science was conducted for studies published between 2012 and 2026, including randomized trials, registries, cohort studies, and systematic reviews. Results Major complications reviewed included Stroke, Delirium, Conduction disturbances (CD) and Arrhythmias, Bleeding/Vascular(access) site injuries/Paravalvular leak (PVL), Acute Kidney Injury (AKI), Structural valve degeneration and thrombosis, Infective Endocarditis (IE) and Coronary Obstruction (CO). Conclusions TAVR complications remain multifactorial, and their incidence and management continue to shift with device evolution and procedural experience. Optimized patient selection, procedural refinement, frailty assessment, and individualized antithrombotic strategies remain important areas for improving outcomes.
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Rezaei et al. (2026) conducted a review in Severe aortic stenosis. Transcatheter aortic valve replacement (TAVR) was evaluated. Transcatheter aortic valve replacement complications remain multifactorial, including stroke, bleeding, and conduction disturbances, which shift with device and procedural evolution.
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