Comparing the HEARTS 2.0 and 2025 AHA/ACC BP guidelines highlights opportunities for contextual adaptation in implementing intensive blood pressure control across primary health care systems in the Americas.
the reduction of CVD risk with sustained BP lowering over a relatively long period and by demonstrating the benefit of early initiation of intensive BP lowering with a diminishing CVD reduction if treatment is delayed. Multiple analyses have reported that intensive vs standard SBP goals produce costs per quality-adjusted life years gained that are below accepted willingness-to-pay levels. 6 A time-to-benefit analysis found that 9, 19, and 34 months of intensive SBP lowering was needed to prevent 1 major adverse cardiovascular event per 500, 200, and 100 patients, respectively. 5 The authors concluded that an intensive SBP goal may be appropriate for adults with a life expectancy of 3 or more years, which can be assessed with the use of a validated life expectancy calculator.
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Muntner et al. (2025) conducted a review in Hypertension and Cardiovascular-Kidney-Metabolic (CKM) syndrome. Intensive systolic blood pressure control and integrated CKM care vs. Standard systolic blood pressure control was evaluated.
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