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Annulated 2-amino-thiophene-3-carbonitriles, obtained by the Gewald reaction from 2,2-dimethylpyran-4-one, cyclopentanone, cyclohexanone, cycloheptanone and 4-(tert-butyl)cyclohexan-1-one, reacted with aromatic aldehydes to obtain Schiff bases. A docking study of the synthesized compounds on four targets was conducted, and their antitumor, antimicrobial, antifungal and antioxidant activities were studied.
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Martirosyan et al. (2026) studied this question.
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