Prevalence and clinical predictors of myocardial injury in patients with acute supraventricular tachycardia

Q: What are the key findings of this study?

Myocardial injury occurred in 50.7% of patients with acute SVT and was independently predicted by longer time since SVT onset (OR 1.334), initial heart rate, and serum creatinine levels.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Acute supraventricular tachycardia (SVT) (n=292). Intervention: Time since SVT onset vs. Shorter duration. Primary outcome: Myocardial injury defined as high-sensitivity cardiac troponin T (hs-cTnT) elevation ≥14 ng/L (OR 1.334, 95% CI 1.161-1.532, p=<0.001).

Q: What does this research mean for the field?

Myocardial injury occurs in approximately half of patients presenting with acute supraventricular tachycardia and is independently predicted by time since tachycardia onset, initial heart rate, and serum creatinine levels. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To determine the prevalence of myocardial injury and identify independent clinical predictors of elevated high-sensitivity cardiac troponin T in emergency patients presenting with acute supraventricular tachycardia.

Hui Wei; Hanmo Bao; HU Xiaoqin; Chengzong Li; Man Ni; Baixiang Zhang; Liqi Ge; Fei Li; Chaoqun Zhang

doi:10.1186/s13019-026-04689-3

October 16, 2026Journal of Cardiothoracic SurgeryOpen Access

Prevalence and clinical predictors of myocardial injury in patients with acute supraventricular tachycardia

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Key result

Longer time since acute SVT onset is linked to ~33% higher odds of myocardial injury.

OR 1.334
95% CI 1.161-1.532
P<0.001
n=292

Why the study?

The precise relationship between myocardial injury and acute supraventricular tachycardia remains unclear despite observations in small studies.

Key Points

To determine the prevalence of myocardial injury and identify independent clinical predictors of elevated high-sensitivity cardiac troponin T in emergency patients presenting with acute supraventricular tachycardia.
Conducted a retrospective, single-center analysis of 292 adult patients presenting with acute supraventricular tachycardia (SVT) to an emergency department between November 2019 and February 2024.
Categorized patients based on high-sensitivity cardiac troponin T (hs-cTnT) status and evaluated independent predictors of elevation using multivariable logistic regression and receiver operating characteristic analysis.
High-sensitivity cardiac troponin T elevation was present in 148 patients (50.7%), with a median hs-cTnT level of 33.6 ng/L compared with 7.4 ng/L in the 144 hs-cTnT-negative patients (49.3%).
Multivariate analysis identified serum creatinine (OR = 1.038, 95% CI: 1.018–1.059, P < 0.001), initial heart rate (OR = 1.032, 95% CI: 1.014–1.051, P = 0.001), and time since SVT onset (OR = 1.334, 95% CI: 1.161–1.532, P < 0.001) as independent predictors of myocardial injury.
The multivariable prediction model achieved an area under the curve of 0.824 (95% CI: 0.776–0.872, P < 0.001), with a sensitivity of 78.4% and specificity of 74.3%.

Study Design

Type

Observational (n=292)

Multicenter

No

Structured PICO

P

Population

292 adult patients with acute supraventricular tachycardia presenting to the emergency department, evaluated for the prevalence and predictors of myocardial injury.

O

Outcome

Myocardial injury, defined as high-sensitivity cardiac troponin T (hs-cTnT) level > 14 ng/L at emergency department presentationsurrogate

Main Result

Odds Ratio: 1.334 (95% CI 1.161–1.532)

p-value: p=<0.001

Myocardial injury is common during acute supraventricular tachycardia, affecting roughly half of patients, and is independently predicted by elevated initial heart rate, longer duration since symptom onset, and higher serum creatinine levels.

Limitations

Retrospective, single-center design with potential selection bias due to selective troponin testing
Limited sample size
Symptom duration based on patient recall
Lack of serial troponin measurements
Systematic coronary evaluation was not performed
Lack of internal or external validation for the prediction model
Limited sample size due to low proportion of SVT among ED visits and selective troponin testing
Retrospective study design hindered accurate collection of potential confounding variables like family history
Selection bias from physician and patient preference regarding troponin testing in the ED
Comorbidities such as active infection, CAD, heart failure, or renal failure were not excluded by design
Symptom duration was based on patient recall, and serial troponin measurements were unavailable for most patients
Lack of systematic coronary evaluation and lack of internal or external validation for the prediction model

Implication

Myocardial injury affects half of acute SVT cases and associates with onset delay, rate, and creatinine; hypothesis-generating for risk stratification pending prospective validation.

Abstract

Myocardial injury without overt ischemia accounts for approximately 30% of all myocardial injury cases and is associated with worse outcomes, regardless of the underlying cause. Myocardial injury in patients following acute episodes of supraventricular tachycardia (SVT) has been observed in several small-sample studies. However, the precise relationship between myocardial injury and SVT remains unclear. In this retrospective, single-center study, we analyzed the data of 292 adult patients with acute SVT who presented to our emergency department between November 2019 and February 2024. Data on demographics, clinical characteristics, troponin values, and investigation outcomes were extracted from the electronic medical records. All 292 patients were divided into two groups based on their high-sensitivity cardiac troponin T (hs-cTnT) levels. Predictors of troponin level elevation were also assessed. Of the total participants, 148 (50.7%) were classified as hs-cTnT-positive, and 144 (49.3%) were classified as hs-cTnT-negative. Multivariate analysis revealed that hs-cTnT level elevation was independently associated with serum creatinine levels ( P < 0.001), initial heart rate ( P = 0.001), and the time since SVT onset ( P < 0.001). The area under the curve for this model was 0.824 ( P < 0.001), with a sensitivity of 78.4% and specificity of 74.3%. Myocardial injury was frequently observed during acute SVT. Serum creatinine levels, initial heart rate, and the time since SVT onset were identified as independent predictors of myocardial injury.

Discussion

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Cite This Study

Wei et al. (2026) conducted an observational in Acute supraventricular tachycardia (SVT) (n=292). Time since SVT onset vs. Shorter duration was evaluated on Myocardial injury defined as high-sensitivity cardiac troponin T (hs-cTnT) elevation ≥14 ng/L (OR 1.334, 95% CI 1.161-1.532, p=<0.001). Myocardial injury occurred in 50.7% of patients with acute SVT and was independently predicted by longer time since SVT onset (OR 1.334), initial heart rate, and serum creatinine levels.

synapsesocial.com/papers/6ad34de0727baf805bb60ef6 https://doi.org/10.1186/s13019-026-04689-3

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Prevalence and clinical predictors of myocardial injury in patients with acute supraventricular tachycardia

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Prevalence and clinical predictors of myocardial injury in patients with acute supraventricular tachycardia

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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