Key result
Higher Life's Essential 8 score linked to ~25% lower mortality per 10 points in cancer survivors.
Why the study?
Cancer survivors have a higher risk of cardiovascular disease, but the association between Life's Essential 8 cardiovascular health scores and mortality risk in this population was unclear.
Does a higher Life's Essential 8 score reduce all-cause and cardiovascular mortality in cancer survivors?
Cohort (n=2,191)
Does a higher Life's Essential 8 score reduce all-cause and cardiovascular mortality in cancer survivors?
Hazard Ratio: 0.75 (95% CI 0.66–0.85)
p-value: p=<0.001
Higher adherence to Life's Essential 8 cardiovascular health metrics significantly reduces both all-cause and cardiovascular mortality risks among cancer survivors.
Supports CVH promotion in cancer survivors; extends general LE8 findings but hypothesis-generating pending trials.
Background: Life's Essential 8 (LE8), an indicator of cardiovascular health (CVH), can predict overall and cardiovascular mortality in the general population. Considering that cancer survivors have a higher risk of cardiovascular disease (CVD), our study aimed to investigate the association between LE8 and the prognosis of cancer survivors. Methods: A total of 2191 cancer survivors were included from the National Health and Nutrition Examination Survey (2005-2018). LE8 scores, derived from eight individual metrics, were categorized into three groups: low (0-49), moderate (50-79), and high (80-100). Cox regression analysis, nonlinear analysis, sensitivity analysis, and subgroup analysis were conducted to explore the association between LE8 scores and mortality risks, adjusting for potential confounders. Results: During a median follow-up of six years, 479 deaths were recorded, including 118 CVD events and 156 cancer events. LE8 scores showed an inverse linear relationship with all-cause and cardiovascular mortality. A 10-point increase in LE8 scores was associated with a 25 % reduction in all-cause mortality (hazard ratio [HR], 0.75; 95 % CI, 0.66-0.85) and a 29 % reduction in cardiovascular mortality (HR, 0.71; 95 % CI, 0.57-0.89). Additionally, moderate CVH was linked to a lower risk of all-cause mortality (HR, 0.55; 95 % CI, 0.37-0.81), while high CVH was associated with an even lower risk (HR, 0.35; 95 % CI, 0.19-0.68). Similarly, moderate CVH demonstrated a decreased risk of cardiovascular mortality (HR, 0.31; 95 % CI, 0.15-0.63), with high CVH showing an even lower risk (HR, 0.23; 95 % CI, 0.09-0.58). However, LE8 scores was not associated with cancer-specific mortality. Conclusions: A higher LE8 score was independently associated with a decreased risk of both all-cause and cardiovascular mortality in cancer survivors, underscoring the significance of optimizing CVH during the survivorship phase of cancer care.
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Liu et al. (2024) conducted a cohort in Cancer survivors (n=2,191). Life's Essential 8 (LE8) score vs. Lower LE8 score (per 10-point increase reference) was evaluated on All-cause mortality (per 10-point increase in LE8 score) (HR 0.75, 95% CI 0.66-0.85, p=<0.001). A 10-point increase in Life's Essential 8 cardiovascular health scores was independently associated with a 25% reduction in all-cause mortality (HR 0.75) and a 29% reduction in cardiovascular mortality among cancer survivors.
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