Key result
Atrial fibrillation linked to ~41% higher platelet-to-leucocyte ratio in CAD.
Why the study?
The relationships between platelet characteristics and Holter ECG monitoring results in patients with AF and CAD were not well established.
Are platelet characteristics associated with supraventricular arrhythmias and ST-segment episodes in patients with coronary artery disease and atrial fibrillation?
Cross-Sectional (n=300)
Are platelet characteristics associated with supraventricular arrhythmias and ST-segment episodes in patients with coronary artery disease and atrial fibrillation?
Platelet characteristics and amino acid spectrum abnormalities are correlated with supraventricular arrhythmias and ST-segment changes on Holter monitoring, suggesting a role in the pathogenesis of AF in patients with CAD.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating only in CAD-AF; does not support platelet indices for arrhythmia risk stratification or practice change.
OBJECTIVE: Aim: To check the relationships between platelet characteristics and Holter ECG monitoring results in patients with atrial fibrillation (AF) and coronary artery disease (CAD). PATIENTS AND METHODS: Materials and Methods: 300 investigated patients were separated into three groups: I (CAD) - 149 patients with CAD without arrhythmias, II (CAD and AF) - 124 patients with CAD and AF paroxysm, and the control group (CG) - 27 patients without CAD and arrhythmias. RESULTS: Results: In the II group was detected an increase in mean platelet volume (MPV) (9.30%) and platelet-to-leucocyte ratio (PLR) (41.12%) and a decrease in platelet count (PC) (12.20%) in comparison with the I group, P<0.05. Also, in the II group was found an increase in platelet leucine (12.63%), isoleucine (10.73%), and a decrease in serine (5.06%), threonine (23.05%), valine (30.83%), glycine (32.21%) levels in comparison with the I group, P<0.05. PC, MPV, and PLR ratios were correlated with supraventricular extrasystoles per hour (r=-0.352, r=0.308, and r=0.359, consequently), P<0.05. Platelets distribution width (PDW) was correlated with ST-segment changes (r=0.371), P<0.05. Platelet threonine, serine, glycine, alanine, and valine levels were correlated with total supraventricular extrasystoles (r=-0.374, r=-0.358, r=-0.402, r=-0.307, r=-0.312, consequently) and supraventricular extrasystoles per hour (r=-0.374, r=-0.358, r=-0.402, r=-0.307, r=-0.312, consequently), P<0.05. Platelet lysine, taurine, cysteine, and phenylalanine levels were correlated with ST-segment changes (r=-0.319, r=-0.344, r=-0.376, and r=0.317, consequently), P<0.05. CONCLUSION: Conclusions: Platelet features (PC, MPV, PDW, PLR, and amino acid spectrum) are significantly correlated with supraventricular arrhythmias and ST-segment episodes, which shows their role in AF and CAD pathogenesis.
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Melnychuk et al. (2024) conducted a cross-sectional in Coronary artery disease and atrial fibrillation (n=300). Atrial fibrillation in the context of coronary artery disease vs. Coronary artery disease without arrhythmias was evaluated on Mean platelet volume (MPV), platelet-to-leucocyte ratio (PLR), and platelet count (PC) (p=<0.05). In patients with coronary artery disease, the presence of atrial fibrillation was associated with a 9.30% increase in mean platelet volume, a 41.12% increase in platelet-to-leucocyte ratio, and a 12.20% decrease in platelet count compared to those without arrhythmias.
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