Key result
Low-dose yohimbine raises blood pressure and improves clomipramine-induced orthostatic hypotension in depressed patients.
Why the study?
Orthostatic hypotension is a side effect of tricyclic antidepressants that limits adequate dosing, and the effect of yohimbine on this condition was tested.
RCT (n=12)
Double-blind
Supports low-dose yohimbine for clomipramine-induced orthostatic hypotension; confirms alpha-2 antagonism benefit in RCT.
Orthostatic hypotension, one of tricyclic antidepressant treatment's side effects, is also a factor in limiting adequate antidepressant dosing. We tested in a double-blind, crossover, placebo-controlled study the effect of low doses (4 mg/t.i.d.) of yohimbine in 12 patients with depression with clomipramine-induced orthostatic hypotension. Yohimbine, a selective alpha 2-adrenoceptor antagonist, had a favorable effect in orthostatic hypotension and induced a significant increase in blood pressure. A pharmacodynamic and pharmacokinetic interaction between yohimbine and clomipramine or demethylclomipramine was discussed.
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Lacomblez et al. (1989) conducted an RCT in Depression with clomipramine-induced orthostatic hypotension (n=12). Yohimbine vs. Placebo was evaluated on Blood pressure. Low-dose yohimbine (4 mg t.i.d.) induced a significant increase in blood pressure and had a favorable effect on clomipramine-induced orthostatic hypotension in patients with depression.
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