Why the study?
Does yohimbine affect blood pressure and plasma catecholamines differently in untreated hypertensive patients compared to healthy volunteers?
Does yohimbine affect blood pressure and plasma catecholamines differently in untreated hypertensive patients compared to healthy volunteers?
The differential response to yohimbine suggests an alpha 2-adrenoreceptor desensitization or altered balance of alpha-adrenoreceptors in human essential hypertension.
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May raise diastolic BP selectively in hypertensives; extends evidence for alpha2-adrenoreceptor desensitization in essential hypertension.
Musso et al. (1995) studied this question.
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