Key result
Yohimbine administration increased mean arterial pressure by 17% in hypertensive patients and 13% in normotensive controls, with baseline arterial norepinephrine predicting the pressor response.
Why the study?
Does yohimbine alter sympathoadrenal and hemodynamic responses in patients with essential hypertension compared to normotensive controls?
Does yohimbine alter sympathoadrenal and hemodynamic responses in patients with essential hypertension compared to normotensive controls?
Absolute Event Rate: 17% vs 13%
A yohimbine challenge test can identify patients with pressor hyperresponsiveness due to excessive sympathoadrenal reactivity.
No takes yet. Share an insight, caveat, or question.
May flag sympathoadrenal hyperreactivity in hypertension; leaves open diagnostic utility and causal role.
Goldstein et al. (1991) studied Essential hypertension (n=38). Yohimbine vs. Normotensive control subjects was evaluated on Increase in mean arterial pressure. Yohimbine administration increased mean arterial pressure by 17% in hypertensive patients and 13% in normotensive controls, with baseline arterial norepinephrine predicting the pressor response.
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