Key result
The homozygous AA genotype of the AQP-2 rs3759126 polymorphism was significantly associated with hypertension compared to healthy controls (OR 2, p=0.04).
Why the study?
Genetic variation of the Aquaporin-2 gene in relation to hypertension and chronic kidney disease was not well characterized.
Case-Control (n=120)
No
The present study aims to examine the genetic variation of the Aquaporin-2 gene concerning hypertension and chronic kidney disease CKD. (120 ) blood samples from participants were obtained and divided into three groups: a first group representing hypertensive patients (hyper), a second group representing Hypertensive CKD patients (hyper with CKD), and a third group representing a control group. DNA was extracted from all blood samples and then converted to cDNA and the ARMS-PCR technique was used to investigate the single nucleotide polymorphism (SNP) from the AQP-2, genes. The result of this study investigated that SNP rs3759126 located in AQP-2 is a significant association with hypertension and CKD.
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Qahtan et al. (2022) conducted a case-control in Hypertension and Chronic Kidney Disease (n=120). Aquaporin-2 (AQP-2) rs3759126 AA genotype vs. Control group was evaluated on Association of AQP-2 rs3759126 AA genotype with hypertension (OR 2, 95% CI 0.7695-5.1983, p=0.04). The homozygous AA genotype of the AQP-2 rs3759126 polymorphism was significantly associated with hypertension compared to healthy controls (OR 2, p=0.04).
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