Key result
Oral diazoxide triggers reversible extrapyramidal symptoms in ~15% of severely hypertensive patients.
Why the study?
Extrapyramidal symptoms have been observed in hypertensive patients treated with oral diazoxide, but their characteristics and management were not well described.
Case Report (n=100)
No
Answers are grounded in this paper and cite their sources.
Warrants vigilance for extrapyramidal symptoms with oral diazoxide; hypothesis-generating for serum-level associations in severe hypertension.
Extrapyramidal symptoms developed a variable time after the start of treatment with oral diazoxide in 15% of a series of 100 severely hypertensive patients. Six illustrative cases are described. Treatment with diazoxide could be continued in four of these. The symptoms are usually controllable either by dosage adjustment or by the use of diazepam or procyclidine. There was no evidence of irreversibility of the extrapyramidal syndromes observed.
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Neary et al. (1973) conducted a case report in Severe hypertension (n=100). Diazoxide was evaluated on Development of extrapyramidal symptoms.
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