Diazoxide reduced mean lying blood pressure from 228/152 mm Hg to 153/95 mm Hg and achieved rapid initial and good long-term control of severe drug-resistant hypertension, accompanied by significant improvement in renal function.
Observational (n=39)
No
Treatment with intravenous and oral diazoxide was given to a group of 39 patients suffering from severe drug-resistant hypertension associated with renal impairment. Rapid initial and good long-term control of hypertension was achieved in all cases without the production of clinically significant postural hypotension. The side effects of diazoxide, including its diabetogenic effect, were easily controlled. There was a highly significant improvement in renal function in most patients on long-term oral diazoxide therapy.Diazoxide may have an important place in both the short- and long-term therapy of resistant hypertension, particularly in association with renal damage.
Pohl et al. (1971) conducted an observational in Severe drug-resistant hypertension with renal impairment (n=39). Diazoxide was evaluated on Blood pressure control. Diazoxide reduced mean lying blood pressure from 228/152 mm Hg to 153/95 mm Hg and achieved rapid initial and good long-term control of severe drug-resistant hypertension, accompanied by significant improvement in renal function.