Key result
Intravenous diazoxide treatment for refractory hypertension resulted in acute diabetic ketoacidosis in a 29-year-old nondiabetic woman with impaired renal function.
Why the study?
Does intravenous diazoxide cause diabetic ketoacidosis in patients with refractory hypertension and impaired renal function?
Case Report (n=1)
No
Does intravenous diazoxide cause diabetic ketoacidosis in patients with refractory hypertension and impaired renal function?
Intravenous diazoxide treatment for refractory hypertension can be complicated by acute diabetic ketoacidosis, even in nondiabetic patients with impaired renal function.
Answers are grounded in this paper and cite their sources.
May alert to DKA risk with IV diazoxide in nondiabetics with renal impairment; single case leaves causality and generalizability open.
IT has been reported that severe arterial hypertension can be treated effectively and safely with diazoxide given in a series of intravenous injections.1 , 2 During such treatment we have observed the appearance of diabetic ketoacidosis in a nondiabetic patient with impaired renal function.Case ReportA 29-year-old woman, previously in good health, was admitted to the University of Wisconsin Hospitals in July, 1966, after the abrupt onset of hematuria, hypertension, oliguria and azotemia. Renal biopsy on the 19th day of oliguria revealed changes consistent with glomerulonephritis. Treatment with azathioprine was begun, and dialytic support continued until the acute renal failure resolved. . . .
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Updike et al. (1969) conducted a case report in Refractory hypertension (n=1). Intravenous diazoxide was evaluated on Diabetic ketoacidosis. Intravenous diazoxide treatment for refractory hypertension resulted in acute diabetic ketoacidosis in a 29-year-old nondiabetic woman with impaired renal function.
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