Diazoxide and Myocardial Ischemia

Comments1 September 1976Diazoxide and Myocardial IschemiaMICHAEL H. ROSOVE, M.D.MICHAEL H. ROSOVE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-395_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: In a recent issue of this journal, Kanada and colleagues (1) report a high incidence of cardiac ischemic manifestations after the use of diazoxide (Hyperstat® IV) for severe hypertension. They postulate that the rapid fall in blood pressure and resulting regional decrease in coronary blood flow in patients with obstructive coronary artery lesions was responsible. A reflex tachycardia after drug administration may be important in some instances. A 62-year-old white woman was normotensive 1 year before admission but became hypertensive during the year. She came to the emergency room having had headaches and vomiting for 3 days....References1. KANADAKANADAHUTCHINSON SDR: Angina-like syndrome with diazoxide therapy for hypertensive crisis. Ann Intern Med 84:696-699, 1976 LinkGoogle Scholar2. RUBINROTHTAYLOR AFR: Pharmacology of diazoxide, an antihypertensive, nondiuretic benzothiadiazine. J Pharmacol Exp Ther 136:344-352, 1962 MedlineGoogle Scholar3. HAMBYJANKOWSKIPOUGET WGJ: Intravenous use of diazoxide in the treatment of severe hypertension. Circulation 37:169-174, 1968 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine UCLA Center for the Health Sciences Los Angeles, CA 90024 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGENETIC STUDIES OF HYDATIDIFORM MOLESHAZARDS OF INTRAVENOUS DIAZOXIDEBlood pressure reduction by incremental infusion of labetalol in patients with severe hypertension.Hypotensive drugsLABETALOL IN HYPERTENSION 1 September 1976Volume 85, Issue 3Page: 395-395KeywordsCoronary arteriesDrug administrationEmergency departmentFallsHypertensionIschemiaLesionsReflexesTachycardiaVomiting Issue Published: 1 September 1976 PDF downloadLoading ...