Key result
Diazoxide reduced mean blood pressure from 171/98 mm Hg to 146/87 mm Hg over four days in hypertensive patients, though it caused sodium and water retention.
Why the study?
Does diazoxide reduce blood pressure and alter renal electrolyte excretion in hypertensive patients?
Does diazoxide reduce blood pressure and alter renal electrolyte excretion in hypertensive patients?
Answers are grounded in this paper and cite their sources.
Diazoxide effectively lowers blood pressure in hypertensive patients despite causing sodium and water retention, demonstrating that the antihypertensive effect of benzothiadiazines can occur independently of natriuresis.
In a study of its cardiovascular actions, Rubin et al (1961) reported that diazoxide produced a fall in blood pressure in renal hypertensive dogs and metacorticoid hypertensive rats without increasing sodium excretion. On isolated aortic strip preparations, this new benzothiadiazine was shown to inhibit contractions induced by noradrenaline, 5-hydroxytryptamine, and angiotensin. Previous studies have indicated that the blood-pressure of hypertensive patients treated with chlorothiazide may fall in the absence of a natriuretic response (Hollander et al, 1959). The present study was therefore designed to examine the effects of diazoxide on the blood-pressure and renal electrolyte excretion patterns of hypertensive patients to determine whether the antihypertensive and diuretic properties of the benzothiadiazines could be separated. Changes in water and electrolyte metabolism in relation to blood-pressure responses were studied. Two of the cases were also treated with trichlor methiazide to observe the effects of combining diazoxide with a thiazide diuretic.
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Hutcheon et al. (1962) studied Hypertension (n=10). Diazoxide vs. Baseline was evaluated on Mean blood pressure reduction (p=<0.01). Diazoxide reduced mean blood pressure from 171/98 mm Hg to 146/87 mm Hg over four days in hypertensive patients, though it caused sodium and water retention.
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